Polymorphisms of interleukin-6 and tumor necrosis factor gene promoters and cardiorespiratory function following
J Arranz Duran1, A Arteaga González, D Domínguez García
1Liver Transplant Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain. javierarranz@telefonica.net
Introduction:
The interindividual variability in cardiorespiratory function during liver transplantation (OLT) has been attributed to various factors, including polymorphisms in immunity genes known to affect the circulation levels of cytokines.
Aim:
To evaluate polymorphisms of genes encoding for interleukin-6 (IL6) and tumor necrosis factor (TNF) in association with cardiorespiratory function in OLT.
Design:
Prospective observational study.
Patients And Methods:
We studied 62 consecutive patients who had OLT performed in our hospital between 2004 and 2005. Polymorphisms at positions -308 and -409 of TNF gene, as well as those at -174 and -574 of IL6 gene were determined in all patients by means of PCR-RFLPs. Associations were carried out using chi-square tests and analysis of variance. A bilateral P < .05 was accepted as significant.
Results:
No statistically significant associations were observed.
Conclusions:
A relationship between the polymorphisms studied and respiratory function in OLT was lacking. These results must be interpreted with caution due to the limited sample size.
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