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Related Experiment Videos

Ciprofloxacin in typhoid fever.

A Bavdekar1, M Chaudhari, S Bhave

  • 1Department of Pediatrics, K.E.M. Hospital, Pune.

Indian Journal of Pediatrics
|May 1, 1991
PubMed
Summary

This study on typhoid fever in children found high resistance to common antibiotics. Ciprofloxacin proved effective and safe for treatment, showing promise for managing this serious infection.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Typhoid fever remains a significant pediatric health concern, particularly in regions with limited access to effective treatments.
  • Antibiotic resistance in Salmonella Typhi is a growing global challenge, complicating treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy and safety of ciprofloxacin in treating pediatric typhoid fever.
  • To assess the in vitro antibiotic susceptibility patterns of Salmonella Typhi isolates.

Main Methods:

  • Retrospective analysis of 78 hospitalized children diagnosed with typhoid fever.
  • In vitro susceptibility testing of Salmonella Typhi isolates against various antibiotics.
  • Clinical evaluation of treatment outcomes in children receiving ciprofloxacin.

Main Results:

  • High resistance rates were observed for chloramphenicol (90%), ampicillin (93%), and co-trimoxazole (97%).
  • Salmonella Typhi isolates demonstrated high sensitivity to ciprofloxacin.
  • Ciprofloxacin treatment in 73 children was effective in disease control and relapse prevention with no noted serious side effects.

Conclusions:

  • Ciprofloxacin is a highly effective and safe therapeutic option for pediatric typhoid fever, especially in areas with multidrug-resistant strains.
  • The study highlights the urgent need for updated treatment guidelines due to widespread antibiotic resistance.

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