Wegener granulomatosis presenting as epididymitis
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Updated: Jun 23, 2026

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
Published on: December 12, 2025
D Chris Miller1, Michael N Koss
1Department of Infectious Disease, University of Southern California Keck School of Medicine, Los Angeles County, CA 90033, USA. chrismil66@hotmail.com
Abstract:
Isolated epididymitis is a very rare presentation of Wegener granulomatosis (WG). Only 1 such case has been previously reported. We report a case of epididymitis in which WG was not suspected clinically or pathologically at orchiectomy, and the patient subsequently developed pulmonary involvement with WG. WG was ultimately diagnosed and treated after lung biopsy several months after the orchiectomy. The retrospective pathologic review of the orchiectomy specimen confirmed the presence of WG in the epididymis; the testicular tissue was not involved.
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