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Related Concept Videos

Silica Gel Column Chromatography: Overview01:10

Silica Gel Column Chromatography: Overview

Silica gel column chromatography is a technique for separating compounds using a column packed with silica gel as the stationary phase. This method relies on differences in the polarity of compounds. Based on their polarities, compounds move between the stationary phase (silica gel) and the mobile phase (the solvent), forming discrete bands in the column.
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
Ion Exchange01:17

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
Size-Exclusion Chromatography01:08

Size-Exclusion Chromatography

In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...
Principles Of Column Chromatography01:13

Principles Of Column Chromatography

The chromatography technique was first invented in 1901 by Michael S. Tswett, a Russian botanist, to separate plant pigments using organic solvents. Further, in 1941, Archer John Porter Martin and R. L. M. Synge modified the technique by packing silica gel into a column. A mixture of amino acids was then separated on the packed column using chloroform and water mixture as the mobile phase. This was the first report on column chromatography. At present, column chromatography is a widely used...
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...

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Related Experiment Video

Updated: Jun 23, 2026

Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level
08:53

Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level

Published on: June 6, 2018

One column operation for (90)Sr/(90)Y separation by using a functionalized-silica.

Jun Sig Lee1, Ul-Jae Park, Kwang-Jae Son

  • 1Korea Atomic Energy Research Institute, 1045 Daedeuk-daero, Deukjin-dong, Yuseong-gu, Daejeon, South Korea. jlee15@kaeri.re.kr

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|April 21, 2009
PubMed
Summary

New organo-ceramic hybrid materials efficiently separate Strontium-90/Yttrium-90 (90Sr/90Y) generators. These advanced materials offer improved Yttrium-90 (90Y) extraction, minimizing waste and radiolytic byproducts for higher purity.

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Last Updated: Jun 23, 2026

Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level
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Published on: June 6, 2018

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Area of Science:

  • Materials Science
  • Radiochemistry
  • Nuclear Engineering

Background:

  • Current methods for Yttrium-90 (90Y) extraction from Strontium-90 (90Sr) generators often involve solvent extraction or column operations.
  • Existing techniques can lead to waste generation and leaching of radiolytic products, impacting the purity and safety of 90Y.
  • The development of novel separation media is crucial for improving the efficiency and environmental impact of 90Y production.

Purpose of the Study:

  • To synthesize and evaluate novel organo-ceramic hybrid materials for the separation of 90Y from 90Sr.
  • To investigate the performance of these hybrid materials as extraction media in a 90Sr/90Y generator system.
  • To assess the efficiency and purity of 90Y recovered using these advanced materials.

Main Methods:

  • Synthesis of organo-phosphorus functionalized organo-ceramic hybrid materials.
  • Implantation of extracting molecules onto ceramic surfaces to create hybrid materials with combined properties.
  • Testing the synthesized materials as separation media in a small Sep-Pak type column for adsorptive extraction of 90Y.

Main Results:

  • The organo-ceramic hybrid materials demonstrated high performance in extracting 90Y.
  • Recovery rates exceeding 92% for 90Y were achieved with a 90Sr/90Y contamination ratio of 1.2x10(-5).
  • Further optimization yielded 70% recovery with an even lower contamination ratio of 5x10(-7).

Conclusions:

  • Organo-ceramic hybrid materials represent a promising advancement in separation media for 90Sr/90Y generators.
  • These materials offer a more efficient and cleaner alternative to traditional extraction methods.
  • The developed technology has the potential to significantly improve the quality and safety of 90Y production.