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Updated: Jun 23, 2026

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
A unique group I intron in Coxiella burnetii is a natural splice mutant
Rahul Raghavan1, Linda D Hicks, Michael F Minnick
1Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA.
Abstract:
Cbu.L1917, a group I intron present in the 23S rRNA gene of Coxiella burnetii, possesses a unique 3'-terminal adenine in place of a conserved guanine. Here, we show that, unlike all other group I introns, Cbu.L1917 utilizes a different cofactor for each splicing step and has a decreased self-splicing rate in vitro.
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