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Updated: Jun 23, 2026
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
Published on: July 18, 2025
Basic research models for the study of underlying mechanisms of electrical neuromodulation and ischemic heart-brain
Mike J L Dejongste1, Gert J Terhorst, Robert D Foreman
1Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. M.J.L.de.Jongste@Thorax.UMCG.nl
Abstract:
The study of mechanisms of action underlying the use of electrical neuromodulation for angina and myocardial ischemia may illuminate heart-brain interactions that influence these conditions. To investigate these mechanisms of action, we initiated a neurocardiology program in the 1990s. This review discusses the experimental models we have studied to unravel the heart-brain interactions involved in the use of electrical neuromodulation for ischemic disease.
