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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jun 23, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Posttransplant lymphoproliferative disorders.

Asim Chughtai1, Bahar Bastani

  • 1Division of Nephrology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri 63110, USA.

Iranian Journal of Kidney Diseases
|April 21, 2009
PubMed
Summary

Posttransplant lymphoproliferative disorder (PTLD) is a serious condition rising with immunosuppression, often linked to Epstein-Barr virus. New treatments offer hope for preventing and managing this potentially fatal disease.

Related Experiment Videos

Last Updated: Jun 23, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Posttransplant lymphoproliferative disorder (PTLD) is a significant complication following organ transplantation.
  • PTLD encompasses a spectrum of clonal lymphoid hyperplasias and malignancies.
  • Mortality rates associated with PTLD can be as high as 60%.

Purpose of the Study:

  • To review the current understanding of PTLD.
  • To highlight the increasing incidence of PTLD.
  • To discuss the role of Epstein-Barr virus (EBV) and emerging therapeutic strategies.

Main Methods:

  • Review of existing literature on PTLD.
  • Analysis of the association between immunosuppressive agents and PTLD incidence.
  • Examination of the etiological role of Epstein-Barr virus in PTLD pathogenesis.

Main Results:

  • PTLD incidence has increased over the past two decades, correlating with potent immunosuppressive therapies.
  • Epstein-Barr virus is implicated in over 90% of PTLD cases.
  • Current standard protocols for PTLD prevention and treatment are lacking.

Conclusions:

  • PTLD is a serious, potentially fatal complication of transplantation.
  • EBV plays a critical role in the majority of PTLD cases.
  • Emerging therapeutic agents show promise for PTLD management and prevention.