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Membranous glomerulonephritis associated with ulcerative colitis.
Atieh Makhlough1, Hafez Fakheri
1Division of Nephrology, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran. makhlough_a@yahoo.com
Iranian Journal of Kidney Diseases
|April 21, 2009
Summary
Glomerulonephritis, a kidney disease, can rarely manifest outside the intestines in patients with inflammatory bowel disease. This case highlights ulcerative colitis as a cause of membranous glomerulonephritis and acute kidney failure.
Area of Science:
- Nephrology
- Gastroenterology
- Internal Medicine
Background:
- Glomerulonephritis is a recognized but uncommon extraintestinal manifestation of inflammatory bowel disease (IBD).
- Inflammatory bowel disease encompasses chronic conditions such as ulcerative colitis and Crohn's disease.
- Membranous glomerulonephritis is a common cause of nephrotic syndrome in adults.
Observation:
- A 69-year-old woman with a history of nephrotic syndrome presented with acute kidney failure.
- The patient also experienced bloody diarrhea and other gastrointestinal symptoms.
- Diagnostic workup revealed ulcerative colitis.
Findings:
- The patient was diagnosed with membranous glomerulonephritis, a kidney disorder.
- Ulcerative colitis was identified as the underlying condition.
- The kidney condition appeared 3 years after the initial nephrotic syndrome diagnosis.
Implications:
- This case underscores the importance of considering inflammatory bowel disease in patients with glomerulonephritis.
- Early diagnosis and management of ulcerative colitis may be crucial for kidney outcomes.
- Further research into the mechanisms linking IBD and glomerulonephritis is warranted.
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