Related Experiment Video

Updated: Jun 23, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Elevated serum C-reactive protein level and microalbuminuria in patients with type 2 diabetes mellitus

Mohammad Javad Mojahedi Mojahedi1, Shokoofeh Bonakdaran, Maryam Hami

  • 1Division of Nephrology, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Kidney Diseases
|April 21, 2009
PubMed
Abstract

Insights

High-sensitivity C-reactive protein (HS-CRP) is elevated in type 2 diabetic patients with microalbuminuria, indicating inflammation linked to kidney and cardiovascular disease progression. HS-CRP may serve as a cost-effective marker for diabetic nephropathy.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Microalbuminuria signifies vascular endothelial damage in diabetic patients.
  • Elevated C-reactive protein (CRP) is a recognized cardiovascular risk factor impacting endothelial function.
  • High-sensitivity CRP (HS-CRP) is investigated for its role in diabetic complications.

Purpose of the Study:

  • To investigate the association between microalbuminuria and serum HS-CRP levels in type 2 diabetes mellitus.
  • To assess HS-CRP as a potential indicator of endothelial dysfunction and inflammation in diabetic nephropathy.

Main Methods:

  • Serum HS-CRP levels were measured in 87 type 2 diabetic patients.
  • Patients were categorized into microalbuminuric and normoalbuminuric groups.
  • Statistical analyses, including Pearson correlation, assessed the relationship between HS-CRP, albuminuria, and patient characteristics.

Main Results:

  • Microalbuminuric patients were older and had longer diabetes duration.
  • Mean serum HS-CRP levels were significantly higher in the microalbuminuric group (4.98 mg/L vs. 2.82 mg/L).
  • A significant positive correlation was found between HS-CRP and urine albumin levels (r = 0.43).

Conclusions:

  • Elevated HS-CRP in microalbuminuric type 2 diabetic patients suggests activated inflammatory pathways.
  • This inflammation may contribute to the progression of renal and cardiovascular atherosclerotic disease.
  • HS-CRP shows potential as an accessible and economical marker for assessing diabetic nephropathy, warranting further research.

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.