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Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains.

Chi-kong Lau1, Jennifer L Bachorik, Gideon Dreyfuss

  • 1Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, USA.

Nature Structural & Molecular Biology
|April 21, 2009
PubMed
Summary

Gemin5 protein binds specifically to small nuclear RNA (snRNA) sequences. This WD repeat domain interaction is crucial for the biogenesis of small nuclear ribonucleoproteins (snRNPs), essential spliceosome components.

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