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Updated: Jun 23, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
[Allergic contact dermatitis to topical drugs: a descriptive analysis]
Rosana Lazzarini1, Ida Duarte, Juliana Casagrande Tavoloni Braga
1Clínica de Dermatologia, Santa Casa de São Paulo, São Paulo, SP, Brazil. lazzarini@fototerapia.com.br
Background:
Allergic Contact Dermatitis is a common type of dermatitis, but its multiple etiologies hinder its management.
Objective:
the objective of this study was to evaluate the frequency of sensitization to topical drugs in a university center, to study the main characteristics of the affected population, and to identify the allergens related with the dermatitis.
Methods:
a retrospective and descriptive study with patients submitted to patch tests. The study was conducted with subjects whose patch test to topical drugs was positive.
Results:
329 patients were submitted to patch tests and 42 (13%) had positive and relevant patch tests to topical drugs. Among these patients, 36 (85.7%) had positive patch tests to the principal component and 28 (66.7%) to the other components. Some patients had more than one sensitization. Neomycin was the most important allergen.
Conclusions:
Among the studied patients, sensitization to topical agents happened in 13% of the cases, with slight preference for females and Caucasians. There was elevated sensitization to neomycin, a popular agent among patients and medical doctors.
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