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Association of HDL cholesterol and triglycerides with mortality in patients with heart failure

H F G Freitas1, E A Barbosa, F H F P Rosa

  • 1Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. dclfreitas@incor.usp.br

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 21, 2009
PubMed

Insights

Higher serum HDL cholesterol and triglycerides correlate with better survival rates in heart failure patients. This study investigated lipid profiles and prognosis in 833 outpatients, finding these fats beneficial for heart health outcomes.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Serum lipoproteins are linked to survival in various heart failure types.
  • Prognosis in heart failure patients, including those with Chagas' heart disease, requires further investigation regarding lipid profiles.

Purpose of the Study:

  • To test the association between serum lipoprotein levels and prognosis in a cohort of outpatients with heart failure.
  • To examine the impact of lipid profiles on survival rates in patients with diverse heart failure etiologies.

Main Methods:

  • A cohort of 833 outpatients with New York Heart Association functional classes III and IV heart failure was studied.
  • Survival rates were analyzed using Kaplan-Meier method and Cox proportional hazards models.
  • Lipid profiles were assessed in relation to mortality, considering factors like age, gender, and heart failure etiology.

Main Results:

  • Higher serum triglycerides (HR=0.97) and HDL cholesterol (HR=0.99) were significantly associated with lower mortality.
  • Age, male gender, and idiopathic dilated cardiomyopathy were independently associated with increased mortality.
  • The study included diverse etiologies: ischemic cardiomyopathy (21%), Chagas' heart disease (17%), hypertensive cardiomyopathy (16%), and idiopathic dilated cardiomyopathy (36%).

Conclusions:

  • Elevated serum HDL cholesterol and triglycerides are associated with improved survival in outpatients with heart failure.
  • Lipid profiles, particularly HDL cholesterol and triglycerides, represent potential prognostic markers in heart failure management.
  • Understanding these associations can inform therapeutic strategies for heart failure patients.

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