Related Experiment Video
Updated: Jun 23, 2026
06:19
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
Migration and multiple sclerosis in Alaskan military veterans
Mitchell T Wallin1, William F Page, John F Kurtzke
1Neuroepidemiology Section, Neurology Service, Veterans Affairs Medical Center and MS Center of Excellence-East, NW, Washington, DC 20422, USA. mitchell.wallin@va.gov
Journal of Neurology
|April 21, 2009
Summary
This study suggests Alaska is not a high-risk area for multiple sclerosis (MS). Migration to Alaska before MS onset appears to decrease risk, while migrating away increases it.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- Multiple sclerosis (MS) prevalence varies geographically.
- Understanding MS risk factors, including migration, is crucial for public health.
- Previous studies have not specifically estimated MS prevalence in Alaskan white males, considering migration patterns.
Purpose of the Study:
- To provide the first estimates of multiple sclerosis (MS) prevalence in Alaskan white males.
- To investigate the impact of migration to and from Alaska on MS risk.
- To compare MS prevalence in Alaska with the broader United States population.
Main Methods:
- A case-control cohort study design was used.
- Data were collected from United States (US) veterans service-connected for MS and matched controls.
- Military service entry between 1960 and 1994 was used as the baseline for analysis.
Main Results:
- The estimated prevalence of MS in white males residing in Alaska at service entry was 22/100,000, with a lower rate of 3.2/100,000 for those born in Alaska.
- Individuals migrating from other states to Alaska before MS onset showed a significantly lower prevalence rate (20.6/100,000) compared to US white males.
- Conversely, those born in Alaska but migrating away before service exhibited a significantly elevated prevalence rate of 115/100,000.
Conclusions:
- Alaska does not appear to be a high-risk area for multiple sclerosis (MS).
- Migration to Alaska before MS onset is associated with a decreased risk.
- Migration away from Alaska before MS onset is associated with an increased risk, suggesting environmental or genetic factors influenced by location.
