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Updated: Jun 23, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Sendai virus for cancer immunotherapy.
Yasuji Ueda1, Mamoru Hasegawa, Yoshikazu Yonemitsu
1Department of Gene Therapy, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan. y_ueda@faculty.chiba-u.jp
Methods in Molecular Biology (Clifton, N.J.)
|April 21, 2009
Summary
Sendai virus (SeV) vector infection matures dendritic cells (DCs), enhancing antitumor immunity. This immunostimulatory virotherapy shows promise for potent tumor treatment in preclinical models.
Area of Science:
- Immunology
- Virology
- Cancer immunotherapy
Background:
- Dendritic cells (DCs) are crucial for antitumor immunity.
- Clinical trials of DC vaccinations for cancer immunotherapy since 1995 have shown limited success.
Purpose of the Study:
- To investigate the potential of Sendai virus (SeV) vector infection to enhance DC maturation and antitumor immunity.
- To evaluate SeV vector as an immune booster for tumor treatment.
Main Methods:
- Infection of DCs with SeV vector.
- Assessment of DC maturation.
- Evaluation of antitumor immunity in mouse models.
Main Results:
- SeV vector infection induced DC maturation.
- SeV vector enhanced antitumor immunity in mouse models.
- Immunostimulatory virotherapy using SeV vector demonstrated potent effects.
Conclusions:
- SeV vector infection is a promising strategy for enhancing DC function.
- Immunostimulatory virotherapy represents a novel and potent approach for cancer treatment.
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