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Endocarditis I: Introduction

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Endocarditis III: Medical Management

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Endocarditis IV: Nursing Management

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

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Updated: Jun 23, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Brucella endocarditis - a registry study.

Serkan Cay¹, Goksel Cagirci, Orhan Maden

¹Department of Cardiology, Yuksek Ihtisas Heart-Education and Research Hospital, 06480, Ankara, Turkey. cayserkan@yahoo.com

Kardiologia Polska

|April 21, 2009

Summary

Brucellosis endocarditis, a rare complication of Brucella infection, often presents with fever. Optimal treatment involves a combination of antibiotics and surgery, with third-generation cephalosporins showing promise as an alternative to aminoglycosides.

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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

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Last Updated: Jun 23, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Area of Science:

Infectious Diseases
Cardiology
Internal Medicine

Background:

Brucellosis, a zoonotic infection caused by Brucella spp., is endemic in many regions.
Brucellosis endocarditis is a rare but severe complication, with limited studies on its characteristics and optimal treatment.
Lack of consensus exists regarding the best medical and interventional therapies for Brucella endocarditis.

Purpose of the Study:

To elucidate the clinical characteristics of Brucella endocarditis.
To determine the optimal therapeutic strategies, including medical and surgical interventions.
To evaluate the efficacy of alternative antibiotic regimens for Brucella endocarditis.

Main Methods:

A retrospective study included 10 patients diagnosed with Brucella endocarditis over a 6-year period.
Data collected included patient demographics, clinical signs and symptoms, drug history, and clinical condition.
Baseline clinical and laboratory characteristics were evaluated for all participants.

Main Results:

The study population consisted of males with a mean age of 55.9 years; fever was the most common symptom (60%).
Valve pathology was present in 70% of patients, predominantly affecting the aortic valve.
Mortality rate was 30%; combination therapy with tetracycline, rifampicin, and third-generation cephalosporins plus aortic valve replacement showed good clinical results with 20% mortality.

Conclusions:

Brucella endocarditis should be considered in patients with cardiac valve vegetations, particularly in endemic areas.
Combined antibiotic and surgical therapy appears to be the optimal treatment approach.
Medical therapy may be an alternative for stable patients, and third-generation cephalosporins can be considered instead of aminoglycosides in combination regimens.