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Related Experiment Video

Updated: Jun 23, 2026

Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

Published on: July 23, 2013

A critical role for myoglobin in zebrafish development.

Danielle H Vlecken¹, Janwillem Testerink, Elisabeth B Ott

¹Institute of Biology, Department of Integrative Zoology, University of Leiden, Leiden 2333 AL, The Netherlands.

The International Journal of Developmental Biology

|April 21, 2009

Summary

Myoglobin is crucial for zebrafish development, impacting cardiac function, angiogenesis, and gut formation. This study reveals its expression patterns and essential roles during embryogenesis, even under hypoxic stress.

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Last Updated: Jun 23, 2026

Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

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Published on: July 23, 2013

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity

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Published on: June 16, 2022

Analysis of Embryonic and Larval Zebrafish Skeletal Myofibers from Dissociated Preparations

Analysis of Embryonic and Larval Zebrafish Skeletal Myofibers from Dissociated Preparations

Published on: November 13, 2013

Area of Science:

Developmental Biology
Molecular Biology
Zebrafish Models

Background:

The globin family, including myoglobin, is vital for oxygen transport.
Myoglobin's role in cardiac development is known, but its embryonic gene regulation is uncharacterized.

Purpose of the Study:

To elucidate the spatial and temporal expression of myoglobin during zebrafish embryogenesis.
To investigate the impact of hypoxic stress on myoglobin expression.
To determine the functional role of myoglobin in zebrafish development.

Main Methods:

Whole mount in situ hybridization to visualize myoglobin mRNA.
Targeted gene knockdown using morpholinos.

Main Results:

Myoglobin exhibits ubiquitous maternal expression, followed by novel non-muscular domains.
Hypoxia induces myoglobin expression in skeletal muscle and the dorsal aorta.
Myoglobin knockdown causes developmental defects including curvature, vascular issues, and gut reduction.

Conclusions:

Myoglobin plays a critical role in zebrafish embryonic development.
Myoglobin is essential for proper angiogenesis and gut development.
Myoglobin expression is regulated by developmental stage and hypoxic conditions.