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Related Experiment Video

Updated: Jun 23, 2026

Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

Recent developments in anti-inflammatory natural products.

Raju Gautam1, Sanjay M Jachak

  • 1Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S Nagar, Mohali-160 062, Punjab, India.

Medicinal Research Reviews
|April 21, 2009
PubMed
Summary

Natural products offer a promising alternative to conventional anti-inflammatory drugs, with fewer side effects. This review highlights plant and marine-derived compounds with potential for developing new anti-inflammatory therapies.

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Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Inflammation Research

Background:

  • Inflammatory diseases are increasing globally, particularly in aging populations.
  • Current anti-inflammatory drugs have limitations, including side effects and high costs.
  • Traditional medicines and natural products present an alternative source for novel anti-inflammatory agents.

Purpose of the Study:

  • To review anti-inflammatory natural products from plant and marine sources reported in the last decade.
  • To identify potential lead compounds for drug development.
  • To discuss structure-activity relationships (SAR) and clinical studies of these natural products.

Main Methods:

  • Literature review of scientific publications from the past 10 years.
  • Categorization of identified compounds by chemical class (alkaloids, steroids, terpenoids, polyphenolics, etc.).
  • Analysis of SAR studies and clinical trial data for selected compounds.

Main Results:

  • Numerous anti-inflammatory compounds from diverse chemical classes were identified.
  • Key potential lead compounds include curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid.
  • SAR studies and clinical data provide insights into the efficacy and mechanisms of action.

Conclusions:

  • Natural products represent a valuable resource for discovering novel anti-inflammatory drugs.
  • Further research, including SAR studies and clinical trials, is warranted for promising candidates.
  • These natural compounds could lead to safer and more cost-effective treatments for inflammatory diseases.