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Comparative study on chronic tissue damage after cordectomies using either CO2 laser or microdissection electrodes
Enrique Zapater1, Soledad Frías, Ana Pérez
1ENT Department, Valencia University General Hospital, Valencia Medical School, Spain. ezapaterlatorre@yahoo.es
Head & Neck
|April 21, 2009
Summary
Chronic vocal fold damage from CO(2) laser and microdissection electrodes is similar. Scarring completion for vocal fold tissue occurred between 12 and 20 weeks post-surgery.
Area of Science:
- Otolaryngology
- Laryngeal Surgery
- Tissue Engineering
Background:
- Comparing chronic laryngeal soft tissue damage from microdissection electrodes and CO(2) laser post-cordectomy.
- Assessing tissue response in patients undergoing repeat laryngeal surgery for T1 glottic carcinomas.
Purpose of the Study:
- To evaluate and compare the chronic tissue damage caused by microdissection electrodes versus CO(2) laser in laryngeal surgeries.
- To analyze the degree of collagenization in vocal fold tissues based on the surgical device used and time interval between procedures.
Main Methods:
- Histological examination of laryngeal specimens from 6 patients using Masson trichrome staining.
- Analysis of collagenization grade and level in relation to patient age, interval between surgeries, and surgical device (CO(2) laser or microdissection electrodes).
Main Results:
- Control samples exhibited minimal collagenization.
- Post-operative samples showed moderate, comparable collagenization irrespective of whether a CO(2) laser or microdissection electrodes were used.
- A correlation was found between collagenization level and the time interval between surgical procedures, independent of the device.
Conclusions:
- The chronic vocal fold tissue damage induced by CO(2) laser and microdissection electrodes is similar.
- Vocal fold scar maturation was observed to be complete between 12 and 20 weeks in the studied patient cohort.
