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Comparison of different plateletpheresis systems
1Dept. of Transfusion Medicine and Coagulation Physiology, University Hospital Marburg, FRG.
Infusionstherapie (Basel, Switzerland)
|August 1, 1991
Summary
Comparing cell separators, the COBE Spectra showed superior separation efficiency and purity. However, improper ACD ratios can cause platelet aggregation, impacting function and survival.
Area of Science:
- Hematology
- Biomedical Engineering
- Blood Transfusion Technology
Background:
- Evaluating cell separators requires assessing thrombocyte yield, separation efficiency, and concentrate purity.
- Comparing separation efficiency across different centers and procedures is challenging.
Purpose of the Study:
- To compare the performance of three next-generation cell separators: COBE Spectra, Fresenius AS-104, and Fenwal CS-3000 TNX.
- To evaluate thrombocyte yield, separation efficiency, and purity of platelet concentrates.
Main Methods:
- A multicenter study involving 12 centers provided context.
- Direct comparison of COBE Spectra (n=71), AS-104 (n>1100), and CS-3000 TNX (n=79) in Marburg.
- Analysis of leukocyte contamination and platelet aggregation under varying ACD-blood ratios.
Main Results:
- COBE Spectra demonstrated the best separation efficiency and lowest leukocyte contamination when the ACD ratio was within -15% of the algorithm.
- The AS-104 and CS-3000 TNX had similar separation efficiencies (approx. 60%).
- AS-104 platelet concentrates approached COBE Spectra's purity, while CS-3000 had four times higher leukocyte contamination.
Conclusions:
- COBE Spectra offers superior performance under optimal conditions, with reduced donor risk due to adjusted blood flow.
- Suboptimal ACD ratios can lead to platelet aggregation, compromising platelet function and survival.
- AS-104 shows better overall results compared to CS-3000 regarding purity and thrombocyte quality.