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Calculation of the biological effective dose for piecewise defined dose-rate fits
Robert F Hobbs1, George Sgouros
1Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21231, USA. rhobbs3@jhmi.edu
Abstract:
An algorithmic solution to the biological effective dose (BED) calculation from the Lea-Catcheside formula for a piecewise defined function is presented. Data from patients treated for metastatic thyroid cancer were used to illustrate the solution. The Lea-Catcheside formula for the G-factor of the BED is integrated numerically using a large number of small trapezoidal fits to each integral. The algorithmically calculated BED is compatible with an analytic calculation for a similarly valued exponentially fitted dose-rate plot and is the only resolution for piecewise defined dose-rate functions.
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