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Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking

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Water-soluble BODIPY derivatives.

Song Lin Niu¹, Gilles Ulrich, Raymond Ziessel

¹Laboratoire de Chimie Organique et Spectroscopies Avancées (LCOSA), CNRS, Université Louis Pasteur, Ecole de Chimie, Polymères, Matériaux de Strasbourg (ECPM), 25 rue Becquerel, 67087 Strasbourg, Cedex 02, France.

Organic Letters

|April 22, 2009

Summary

New water-soluble BODIPY dyes were synthesized using sulfonated peptide chains. These novel dyes offer improved solubility for various applications.

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Area of Science:

Organic Chemistry
Materials Science
Dye Chemistry

Background:

BODIPY dyes are known for their photophysical properties but often suffer from poor water solubility.
Developing water-soluble fluorescent probes is crucial for biological and analytical applications.

Purpose of the Study:

To synthesize novel water-soluble BODIPY dyes.
To functionalize BODIPY cores with sulfonated peptide chains to enhance aqueous solubility.

Main Methods:

Synthesis of BODIPY cores.
Introduction of sulfonated peptide chains via coupling or substitution reactions.
Quaternization of dimethylpropargylamine derivatives using propanesultone.

Main Results:

Successfully obtained new water-soluble BODIPY dyes.
The synthesized dyes incorporate sulfonated peptide chains, improving their solubility in water.
The synthetic route provides a versatile method for creating functionalized BODIPY derivatives.

Conclusions:

The developed method efficiently produces water-soluble BODIPY dyes.
These novel dyes hold potential for applications requiring fluorescent probes in aqueous environments.