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Choice reaction time and adequacy of dialysis: a new application of an old method
1University of Washington, Seattle, Washington, U.S.A. sahmad@u.washington.edu
Background:
Choice Reaction Time (CRT) is the time it takes for a subject to accurately respond to a flashing panel of lights. The CRT has been used to assess the quality of dialysis in hemodialysis patients and to assess the neurological impairments in patients with Parkinson's disease.
Methods:
Three groups of end-stage renal disease (ESRD) patients on three different renal replacement therapies were tested using CRT: intermittent peritoneal dialysis (IPD, n = 11), thrice weekly hemodialysis (HD, n = 22), and well-functioning kidney transplant (Tx, n = 6). A group of volunteers with normal renal function (NL, n = 12) was also tested.
Results:
The CRT was significantly longer in IPD patients (618 +/- 89 ms) than observed in the other three groups (p < 0.0001). CRT in HD patients was 461 +/- 50 ms, which was significantly longer than in Tx patients (396 +/- 25 ms, p = 0.05). However, the CRT in the Tx patients was no different from the NL (382 +/- 22, p = 0.32). There was a strong negative correlation between CRT and weekly creatinine clearance in the IPD group (r =- .96) and between the dialysis index and CRT in HD (r =- 0.79).
Conclusions:
CRT may be a useful tool in assessing the adequacy of dialysis.
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