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Peritoneal dialysis using bicarbonate-containing solution sterilized by ultrafiltration.

A W Yu1, F J Manahan, J P Filkins

  • 1Department of Medicine, Veterans Affairs Hospital, Hines, Illinois.

The International Journal of Artificial Organs
|August 1, 1991
PubMed
Summary

Acute peritoneal dialysis using a bicarbonate solution sterilized by ultrafiltration effectively improved azotemia and metabolic acidosis in end-stage renal disease patients, who tolerated the procedure well.

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Area of Science:

  • Nephrology
  • Renal Medicine
  • Dialysis Technology

Background:

  • End-stage renal disease (ESRD) presents significant challenges in managing uremia and metabolic disturbances.
  • Traditional dialysis methods require careful consideration of solution composition and sterilization.
  • Bicarbonate-based solutions are crucial for correcting metabolic acidosis in dialysis patients.

Purpose of the Study:

  • To evaluate the efficacy and tolerance of acute peritoneal dialysis using a novel bicarbonate-containing solution.
  • To assess the impact of this dialysis method on azotemia and metabolic acidosis in ESRD patients.

Main Methods:

  • Acute peritoneal dialysis was administered to eight patients with end-stage renal disease.
  • A bicarbonate-containing dialysis solution was utilized.

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  • Sterilization of the dialysis solution was achieved through ultrafiltration using polyamide filters.

    • Main Results:

    • All eight patients tolerated the acute peritoneal dialysis procedure well.
    • Significant improvements in azotemia were observed post-procedure.
    • Effective correction of metabolic acidosis was demonstrated.

    Conclusions:

    • Acute peritoneal dialysis with a bicarbonate solution sterilized by ultrafiltration is a well-tolerated and effective treatment for ESRD patients.
    • This method successfully addresses key complications of ESRD, namely azotemia and metabolic acidosis.
    • Ultrafiltration offers a viable sterilization technique for peritoneal dialysis solutions.