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Heparinized polyurethane surface through ionic bonding of heparin.
R Barbucci1, A Magnani, A Albanese
1C.R.I.S.M.A. Centro Didattico, Università di Siena, Nuovo Policlinico Le Scotte, Italy.
The International Journal of Artificial Organs
|August 1, 1991
Summary
A new polyurethane-based material (PUPA) enhances blood compatibility by strongly adsorbing heparin. This PUPA material offers improved heparin binding compared to surface-grafted methods, with tunable properties for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Chemistry
Background:
- Polyurethane blood compatibility is often limited.
- Surface heparinization improves hemocompatibility by reducing blood-cell interactions.
- Ionic bonding is a common strategy for surface heparinization.
Purpose of the Study:
- To develop a novel polyurethane-based material (PUPA) with enhanced heparin adsorption capacity.
- To investigate the synthesis and characterization of PUPA materials.
- To evaluate PUPA's potential for biomedical device coatings.
Main Methods:
- Synthesis of poly(amido-amine) and its incorporation into polyurethane via cross-linking with hexamethylenediisocyanate.
- Preparation of surface-grafted poly(amido-amine) on polyurethane for comparison.
- Characterization of native and heparinized materials using Attenuated Total Reflectance Fourier-Transform Infrared (ATR/FT-IR) spectroscopy.
- Physicochemical characterization of PUPA-coated commercial biomedical devices.
Main Results:
- A new material, PUPA, was synthesized by cross-linking poly(amido-amine) with polyurethane.
- PUPA exhibited a higher heparin adsorbing capacity compared to surface-grafted poly(amido-amine) polyurethane.
- Varying component percentages allowed for the creation of PUPA series with distinct physicochemical properties.
- ATR/FT-IR confirmed the successful heparinization and characterized the material properties.
Conclusions:
- PUPA represents a promising biomaterial for improving polyurethane blood compatibility.
- The cross-linked structure of PUPA facilitates superior heparin adsorption.
- Tunable physicochemical properties and coating capabilities make PUPA suitable for biomedical applications.