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Updated: Jun 23, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

[New member miRNA in p53 gene signal pathway - review]

Kou-Rong Miao1, Wei Xu, Jian-Yong Li

  • 1Department of Hematology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|April 22, 2009
PubMed

Insights

Mutations in the p53 pathway are common in cancers. MicroRNAs (miRNAs) are key regulators of protein expression, influencing p53

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Context:

  • The p53 signaling pathway is frequently altered in human cancers.
  • Wild-type p53 acts as a crucial tumor suppressor through transcriptional regulation.
  • MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression post-transcriptionally.

Purpose:

  • To review the role of miRNAs in modulating p53 protein expression.
  • To summarize current research on miRNA biosynthesis and function within the p53 pathway.
  • To highlight the interplay between p53 and miRNAs in cancer biology.

Summary:

  • This review examines how microRNAs (miRNAs) influence protein expression by interacting with the p53 signaling pathway.
  • It details miRNA biosynthesis, their regulatory functions, and their connection to p53's role as a tumor suppressor.
  • The latest findings on miRNAs' impact on p53 activation and downstream effects are discussed.

Impact:

  • Understanding the p53-miRNA axis offers insights into cancer development and progression.
  • Identifies potential therapeutic targets for cancer treatment by modulating miRNA activity.
  • Provides a comprehensive overview of a critical regulatory network in oncology.

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