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Related Concept Videos

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Free-falling Bodies: Introduction01:07

Free-falling Bodies: Introduction

All objects, neglecting air resistance, fall with the same acceleration towards the Earth's center due to the force exerted by the Earth's gravity. This experimentally determined fact is unexpected because we are so accustomed to the effects of air resistance and friction that we expect light objects to fall slower than heavier ones. People believed that a heavier object had a greater acceleration when falling until Galileo Galilei (1564–1642) proved otherwise. We now know this is not the case.
Free-falling Bodies: Example01:05

Free-falling Bodies: Example

An object falling without any air resistance under the influence of gravitational force is said to be in free-fall. For free-falling bodies, the acceleration due to gravity is constant, irrespective of their mass. Free-fall is experienced not only by objects falling downward, but also by all objects whose motion is influenced by gravitational force alone. The dynamics of free-fall motion can be calculated using kinematic equations of motion, since free-fall acceleration is constant.
The...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...

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Related Experiment Video

Updated: Jun 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Fallen immortals.

Tomek Swigut1, Joanna Wysocka

  • 1Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

Cell
|April 22, 2009
PubMed
Summary
This summary is machine-generated.

Somatic cell gene expression memory is reset in the germline through chromatin modifications. The histone demethylase Lsd1/Spr-5 may maintain germ cell epigenetic stability and viability across generations in worms.

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Last Updated: Jun 11, 2026

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

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11:26

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Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
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Published on: January 2, 2016

Area of Science:

  • Epigenetics
  • Developmental Biology
  • Genetics

Background:

  • Somatic cells normally erase epigenetic memory during germline reprogramming.
  • This process involves significant chromatin modification.
  • Maintaining epigenetic stability in germ cells is crucial for reproductive success.

Discussion:

  • Katz et al. (2009) investigate the role of histone demethylase Lsd1/Spr-5 in germline epigenetic resetting.
  • The study focuses on the nematode worm (Caenorhabditis elegans) as a model organism.
  • Lsd1/Spr-5's function is examined in the context of preventing epigenetic drift.

Key Insights:

  • The histone demethylase Lsd1/Spr-5 appears to play a role in the germline resetting of gene expression memory.
  • This enzyme may be essential for preserving the epigenetic integrity of germ cells.
  • Proper function of Lsd1/Spr-5 is linked to sustained germ cell viability over generations.

Outlook:

  • Further research is needed to fully elucidate the molecular mechanisms of Lsd1/Spr-5 in germline epigenetics.
  • Understanding this process could have implications for reproductive health and age-related epigenetic changes.
  • Investigating Lsd1/Spr-5 homologs in other species may reveal conserved roles in germline inheritance.