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Related Experiment Video

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Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

From transcriptome analysis to immunogenomics: current status and future direction.

¹Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan. ohara@kazusa.or.jp

|April 22, 2009

Summary

This study reviews the history and future of immunogenomics, a field combining functional genomics with immune system research. It highlights the power of functional genomic approaches for understanding the human immune system.

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Area of Science:

Genomics
Immunology
Bioinformatics

Background:

Pioneered complementary DNA (cDNA) sequencing for human protein structure prediction in 1994.
Subsequent cDNA sequencing projects extensively characterized the mammalian transcriptome.
Significant efforts were made to develop functional human genomics resources.

Purpose of the Study:

Demonstrate the practical application of functional genomic approaches.
Achieve a comprehensive understanding of the immune system through 'immunogenomics'.
Provide historical context and future perspectives on immunogenomics.

Main Methods:

Review of historical cDNA sequencing projects.
Application of functional genomic approaches to immunogenomics.
Analysis of existing functional genomics resources.

Main Results:

Established the foundation for large-scale cDNA sequencing and transcriptome characterization.
Highlighted the integration of genomics and immunology.
Demonstrated the utility of functional genomics in understanding complex biological systems.

Conclusions:

Immunogenomics offers a powerful framework for dissecting the immune system.
The integration of genomics and functional studies is crucial for future biological research.
The field is poised for significant advancements with continued development of genomic resources and methodologies.