Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing national microinvasive glaucoma surgery procedure rates in response to Medicare and industry payment changes.

Ophthalmology. Glaucoma·2026
Same author

Remote Tonometry Identifies Significant Variability in the Timing of Intraocular Pressure Response to Topical Medication Change.

Ophthalmology. Glaucoma·2026
Same author

The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo.

Science translational medicine·2026
Same author

Photodisruption of the Inner Limiting Membrane Promotes Retinal Engraftment of Stem-Cell Derived Retinal Ganglion Cells.

Investigative ophthalmology & visual science·2026
Same author

Enzymatic Disruption of the Internal Limiting Membrane Enhances Transplanted Retinal Ganglion Cell Survival.

Investigative ophthalmology & visual science·2026
Same author

Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center.

Ophthalmology. Glaucoma·2025

Related Experiment Video

Updated: Jun 23, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Rodent models of glaucoma.

Thomas V Johnson1, Stanislav I Tomarev

  • 1Molecular Mechanisms of Glaucoma Section, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Brain Research Bulletin
|April 22, 2009
PubMed
Summary
This summary is machine-generated.

Rodent models are crucial for understanding glaucoma, a leading cause of irreversible blindness. This review details various rodent models for glaucoma research, aiding therapeutic development.

More Related Videos

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Related Experiment Videos

Last Updated: Jun 23, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Animal Models

Background:

  • Glaucoma is a progressive, age-related optic neuropathy causing irreversible blindness worldwide.
  • Animal models are vital for studying glaucoma's progression and developing treatments.
  • Rodents are increasingly utilized due to cost-effectiveness, availability, and genetic manipulability.

Purpose of the Study:

  • To review in vivo and in vitro rodent models of glaucoma.
  • To discuss methods for generating these glaucoma models.
  • To summarize key findings and evaluate model strengths and weaknesses.

Main Methods:

  • Literature review of rodent models for glaucoma.
  • Analysis of experimental and genetic manipulation techniques.
  • Comparative evaluation of different model systems.

Main Results:

  • Numerous rodent models exist for glaucoma research.
  • Various methods are employed to create these models.
  • Each model offers unique insights but also has limitations.

Conclusions:

  • Rodent models are indispensable tools for glaucoma research.
  • Understanding model-specific advantages and disadvantages is key for effective study design.
  • Continued development of rodent models will advance glaucoma therapeutic strategies.