Cortical bone mineralization differences between hip-fractured females and controls. A microradiographic study

The strength of bone depends on both bone quantity and bone quality. One determinant of bone quality is the degree of mineralization of bone tissue (DMB). To assess the role for DMB in osteoporotic hip fractures, we compared the degree of mineralization in femoral neck cortex from 23 women with hip fractures (age, 65-96 years) and 14 female controls (age, 75-103 years) using quantitative microradiography calibrated with an aluminum step wedge. Variables were DMB in osteons (oDMB(Al)mean) and interstitial tissue (exDMB(Al)mean). Wilcoxon signed-rank tests were used to compare oDMB(Al)mean to exDMB(Al)mean in each group, and Mann-Whitney tests to compare oDMB(Al)mean and exDMB(Al)mean between hip-fracture patients and controls. DMB was significantly lower in the osteons than in the interstitial tissue in both groups (hip-fracture group, P=0.000; control group, P=0.001). DMB values in osteons and interstitial tissue were significantly greater in the hip-fracture patients than in the controls (P=0.007 and P=0.005, respectively). These cross-sectional data suggest that bone fragility may be related to a higher degree of tissue mineralization.