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Related Experiment Video

Updated: Jun 23, 2026

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
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Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

Right ventricular hypertrophy with early dysfunction: A proteomics study in a neonatal model.

Amir M Sheikh1, Cindy Barrett, Nestor Villamizar

  • 1Department of Pediatric Cardiac Surgery, the Neuroproteomics Center, Durham, NC, USA. amsheikh10@hotmail.com

The Journal of Thoracic and Cardiovascular Surgery
|April 22, 2009
PubMed
Summary

This study used proteomics to identify protein changes in neonatal piglets with right ventricular hypertrophy and dysfunction, revealing key proteins involved in the transition from adaptive to maladaptive changes.

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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Published on: November 4, 2015

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Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

Area of Science:

  • Cardiovascular Research
  • Proteomics
  • Neonatal Medicine

Background:

  • Right ventricular hypertrophy and dysfunction are common in congenital heart defects.
  • The molecular mechanisms of adaptive to maladaptive hypertrophy transition are not well understood.

Purpose of the Study:

  • To characterize protein changes in right ventricular myocardium using proteomics.
  • To investigate the molecular mechanisms of right ventricular hypertrophy and dysfunction in a neonatal model.

Main Methods:

  • Neonatal piglets underwent pulmonary artery banding or sham operation.
  • Right ventricular morphology and function were assessed using MRI.
  • Proteomics analysis of right ventricular myocardium was performed using 2D-DIGE and mass spectrometry.

Main Results:

  • Pulmonary artery banding induced significant right ventricular hypertrophy, dilatation, and systolic impairment.
  • Proteomic analysis identified 18 differentially expressed proteins, including structural proteins, metabolic enzymes, and stress proteins.
  • Specific proteins like calsarcin-1 and vinculin increased, while F(1)-ATPase beta-chain and HSP70 decreased.

Conclusions:

  • This is the first study to characterize right ventricular protein changes in a large animal model of neonatal hypertrophy and dysfunction.
  • Findings provide insights into the pathophysiology of neonatal right ventricular hypertrophy and dysfunction.
  • The results can guide future research on molecular mechanisms and therapeutic targets.