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Clomiphene citrate-induced severe hypertriglyceridemia.

Hamiyet Yilmaz Yaşar¹, Ozden Ertuğrul

¹Department of Endocrinology, Aydin State Hospital, Aydin, Turkey. drhamiyetyilmaz@yahoo.com

Fertility and Sterility

|April 22, 2009

Summary

Clomiphene citrate (CC) can cause severe hypertriglyceridemia, especially in women with risk factors for dyslipidemia. Close monitoring of lipid levels is crucial during CC treatment for ovulation induction.

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Area of Science:

Endocrinology
Reproductive Medicine
Clinical Pharmacology

Background:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder often managed with ovulation induction agents.
Clomiphene citrate (CC) is a widely used medication for inducing ovulation.
Hypertriglyceridemia is a lipid disorder that can increase cardiovascular risk.

Observation:

A case report details a 29-year-old overweight woman with PCOS who developed severe hypertriglyceridemia during CC treatment.
The patient had a family history of type 2 diabetes and hyperlipidemia, indicating a predisposition to metabolic disturbances.
Discontinuation of CC and initiation of gemfibrozil led to improvement in lipid levels.

Findings:

Recurrence of severe hypertriglyceridemia was observed upon restarting CC therapy, confirming the association.
The lipid profile normalized again after discontinuing CC and resuming gemfibrozil.
This case highlights a direct link between clomiphene citrate administration and the exacerbation of hypertriglyceridemia.

Implications:

Clomiphene citrate should be prescribed with caution in women with existing risk factors for dyslipidemia.
Routine monitoring of serum lipid levels is recommended for patients undergoing CC treatment, even if baseline levels are normal.
This finding necessitates a re-evaluation of safety protocols for CC use in susceptible populations to prevent severe metabolic complications.