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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Nociception

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Related Experiment Video

Updated: Jun 23, 2026

Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

Numb--from flies to humans.

Benedict Yan1

  • 1Department of Pathology, National University Hospital and Yong Loo Lin's School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore. tranceblues@gmail.com

Brain & Development
|April 22, 2009
PubMed
Summary

Numb is a key molecule that controls cell fate by uneven distribution during cell division. Its role is crucial in human development, cancer, and neurodegenerative diseases.

Area of Science:

  • Cell biology
  • Developmental biology
  • Neurobiology

Background:

  • Numb is the first identified molecule that influences cell fate through asymmetric segregation during cell division.
  • Initially discovered in Drosophila, Numb's significance extends to mammalian and human systems.

Purpose of the Study:

  • To review the current knowledge on Numb.
  • To discuss Numb's relevance in human biology and disease.

Main Methods:

  • Literature review of studies on Numb.
  • Analysis of Numb's role in various biological contexts.

Main Results:

  • Numb's fundamental role in asymmetric cell division and cell fate determination.
  • Numb's involvement in diverse human conditions, including developmental neurobiology, cancer, and neurodegenerative diseases.

More Related Videos

Local and Global Methods of Assessing Thermal Nociception in Drosophila Larvae
10:53

Local and Global Methods of Assessing Thermal Nociception in Drosophila Larvae

Published on: May 18, 2012

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae
07:17

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae

Published on: October 29, 2020

Related Experiment Videos

Last Updated: Jun 23, 2026

Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

Local and Global Methods of Assessing Thermal Nociception in Drosophila Larvae
10:53

Local and Global Methods of Assessing Thermal Nociception in Drosophila Larvae

Published on: May 18, 2012

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae
07:17

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae

Published on: October 29, 2020

Conclusions:

  • Numb is a critical regulator of cell fate with broad implications.
  • Understanding Numb is vital for addressing human diseases.