Related Experiment Video
Updated: Jun 23, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Dialysis access steal syndromes.
Gary W Lemmon1, Michael P Murphy
1Department of Vascular Surgery, Indiana University, Indianapolis, Indiana 46202, USA. gwlemmon@iupui.edu
Dialysis-associated steal syndrome is a challenging complication for vascular surgeons. Prompt diagnosis and treatment are crucial for limb and access salvage, with continued access possible in most cases.
Area of Science:
- Vascular Surgery
- Nephrology
- Ischemic Complications
Background:
- Dialysis-associated steal syndrome (DASS) presents a significant challenge in vascular access surgery.
- Risk factors for DASS include advanced age, diabetes, female sex, cardiac disease, brachial anastomosis, and prior ipsilateral access.
- Diagnosis relies on recognizing a pattern of symptoms and physical findings related to arterial disease and flow dynamics.
Purpose of the Study:
- To emphasize the importance of prompt recognition and treatment of dialysis-associated steal syndromes.
- To highlight the goals of maximizing both limb salvage and vascular access preservation.
- To discuss the management strategies for DASS.
Main Methods:
- Review of clinical presentation and diagnostic challenges in DASS.
- Evaluation of predictive value of digital brachial index (DBI) and transcutaneous oxygen tension (TCPO2).
- Discussion of treatment principles for DASS.
Main Results:
- A digital brachial index (DBI) >1 and transcutaneous oxygen tension (TCPO2) >60 mm Hg can rule out patients at risk for DASS.
- However, no specific DBI or TCPO2 thresholds below these values can accurately predict the development of dialysis-associated ischemia.
- Prompt diagnosis and intervention are key to successful management.
Conclusions:
- Vascular access surgeons must be adept at recognizing and treating DASS to preserve limb and access function.
- While certain objective measures can identify low-risk patients, predicting DASS development in others remains challenging.
- In most cases, continued use of angioaccess in the affected extremity is feasible after successful management of DASS.
Related Concept Videos
Hemodialysis I: Introduction
Hemodialysis II: Procedure and Complications
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Acute Kidney Injury IV: Diagnostic Studies and Prevention

