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Aortic diameter, true lumen, and false lumen growth rates in chronic type B aortic dissection
Kevin J Blount1, Klaus D Hagspiel
1Department of Radiology, University of Virginia, 1000 Lee Street, Charlottesville, VA 22908, USA. kjb6c@virginia.edu
Insights
The aorta and its false lumen grow significantly over time in patients with chronic type B aortic dissection. Rapid aortic growth indicates a higher likelihood of needing surgical repair.
Area of Science:
- Cardiovascular Medicine
- Radiology
- Vascular Surgery
Background:
- Type B aortic dissection (TBAD) is a serious condition affecting the aorta.
- Understanding the long-term aortic growth dynamics in medically managed TBAD is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the growth rates of the aorta, true lumen, and false lumen in patients with chronic type B aortic dissections.
- To identify factors associated with aortic growth and the need for intervention.
Main Methods:
- Serial MDCT angiography and MR angiography scans were used to follow 19 patients with acute type B aortic dissection over a mean of 17.9 months.
- Aortic and lumen dimensions were measured using 3D workstations.
- Linear regression analyses assessed growth rates.
Main Results:
- Maximum aortic diameter increased significantly (7.1 mm/y), driven by false lumen expansion (diameter 6.5 mm/y, area 5.35 cm²/y).
- True lumen also showed significant growth (diameter 0.79 mm/y, area 0.13 cm²/y).
- Patients requiring aortic repair or experiencing death had a significantly higher aortic diameter growth rate (15.4 mm/y) compared to those not intervened upon (1.8 mm/y).
Conclusions:
- The maximum aortic diameter in type B dissections increases significantly over time, primarily due to false lumen enlargement.
- High aortic diameter growth rates are predictive of the need for future endovascular or open surgical aortic repair.
Objective:
The objective of this study was to evaluate growth rates of the aorta, true lumen, and false lumen in chronic type B aortic dissections.
Materials And Methods:
Nineteen consecutive patients with acute type B aortic dissection treated medically between 2000 and 2006 were followed with serial MDCT angiography and MR angiography scans during the chronic phase (mean, 5.3 scans per patient; mean follow-up, 17.9 months). Aortic diameter, true lumen diameter, true lumen area, false lumen diameter, and false lumen area were measured at baseline and at each subsequent follow-up study using 3D workstations. Growth rates were assessed with linear regression analyses.
Results:
One hundred scans were analyzed. The maximum aortic diameter increased significantly over time at a mean rate of 7.1 mm/y (p = 0.004). False lumen diameter (mean, 6.5 mm/y; p = 0.011), false lumen area (5.35 cm(2)/y, p = 0.013), true lumen diameter (0.79 mm/y, p = 0.01), and logarithm true lumen area (0.13 cm(2)/y, p = 0.02) all increased significantly over time, with greater increases in the size of the false lumen than the true lumen. The overall aortic diameter growth rate was significantly higher in patients who ultimately underwent aortic repair or died (15.4 mm/y) than in patients who did not undergo an intervention (1.8 mm/y, p = 0.008).
Conclusion:
Maximum aortic diameter in type B dissections increases significantly over time, primarily because of the increasing size of the false lumen. Patients with high aortic diameter growth rates are more likely to require endovascular or open surgical aortic repair during the chronic phase.
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