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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire

Andrea C Carpenter1, Katherine S Yang-Iott, Linda H Chao

  • 1Immunology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|April 22, 2009
PubMed
Summary

The diversity of T-cell receptor beta (TCRbeta) joining (DJbeta) complexes influences T-cell development and the peripheral Vbeta repertoire. This study reveals how TCRbeta chain selection is impacted by DJbeta complex diversity during thymocyte development.

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