Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

P-value

P-value

P-value is one of the most crucial concepts in statistics.
P-value stands for the probability value. P-value is the probability that, if the null hypothesis is true, the results from another randomly selected sample will be as extreme or more extreme as the results obtained from the given sample.
A large P-value calculated from the data indicates to not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more unlikely...

Pivot Bearings

Pivot Bearings

In mechanical systems, bearings are crucial in facilitating relative motion between two components while minimizing friction and wear. They help distribute various loads (radial, axial or a combination of both loads) across machinery parts, ensuring smooth and efficient operation.
A pivot bearing is a specialized type of bearing designed to support axial loads on a rotating shaft. The bearing surface, or the pivot, is positioned at the end of a shaft to support the axial thrust. The pivot may...

Pulse

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...

Pulse

Pulse

The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls between...

ATP Driven Pumps II: P-type Pumps

ATP Driven Pumps II: P-type Pumps

The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...

Elastic Collisions: Case Study

Elastic Collisions: Case Study

Elastic collision of a system demands conservation of both momentum and kinetic energy. To solve problems involving one-dimensional elastic collisions between two objects, the equations for conservation of momentum and conservation of internal kinetic energy can be used. For the two objects, the sum of momentum before the collision equals the total momentum after the collision. An elastic collision conserves internal kinetic energy, and so the sum of kinetic energies before the collision equals...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual BCL-xL and BCL-2 Inhibition for Advanced Myeloid Neoplasms: A phase 1 dose-escalation study of Navitoclax, Venetoclax, and Decitabine.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

What does BCL-2 do? From new molecular insights to the clinical implications.

Cell death and differentiation·2026

Same author

Drug-tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms.

Cell death and differentiation·2025

Same author

Venetoclax/FluBu2 RIC transplant followed by all-oral venetoclax/decitabine maintenance for poor-risk MDS/AML.

Blood advances·2025

Same author

Dynamic BH3 profiling predicts clinical outcomes in acute myeloid leukemia.

bioRxiv : the preprint server for biology·2025

Same author

<i>TP53</i> mutations drive therapy resistance via post-mitochondrial caspase blockade.

bioRxiv : the preprint server for biology·2025

Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026

Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026

Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026

Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026

Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026

Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

Puma strikes Bax.

Anthony Letai¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. anthony_letai@dfci.harvard.edu

The Journal of Cell Biology

|April 22, 2009

Summary

This summary is machine-generated.

The p53 up-regulated modulator of apoptosis (Puma) protein directly activates the proapoptotic protein Bax, a key step in programmed cell death. This finding clarifies a crucial mechanism in apoptosis regulation.

More Related Videos

Research and Development of High-performance Explosives

Research and Development of High-performance Explosives

Published on: February 20, 2016

Related Experiment Videos

Last Updated: Jun 23, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

Research and Development of High-performance Explosives

Research and Development of High-performance Explosives

Published on: February 20, 2016

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Programmed cell death, or apoptosis, is essential for multicellular organisms.
The mitochondrial pathway of apoptosis is initiated by the activation of proapoptotic proteins Bax or Bak.
Understanding the precise regulation of these proteins is critical for controlling cell death.

Discussion:

This study investigates the direct interaction between Puma and Bax.
The research provides evidence for Puma's role in initiating apoptosis by activating Bax.
The findings contribute to a deeper understanding of the molecular mechanisms governing apoptosis.

Key Insights:

The p53 up-regulated modulator of apoptosis (Puma) protein directly activates the proapoptotic protein Bax.
This direct activation by Puma is a significant step in the commitment to apoptosis.
The study elucidates a novel regulatory mechanism in the mitochondrial apoptosis pathway.

Outlook:

Further research could explore the structural basis of Puma-Bax interaction.
Investigating therapeutic strategies targeting this interaction could be beneficial for diseases involving aberrant apoptosis.
This work opens new avenues for understanding cancer and neurodegenerative disorders.