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A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
Subthalamic nucleus stimulation in Parkinson's disease.
Roberto Marconi1, Andrea Landi, Franco Valzania
1Dipartimento di Neuroscienze Misericordia Ospedale, Azienda USL 9 Grosseto, Via Senese 171, 58100, Grosseto, Italy. r.marconi@usl9.toscana.it
Summary
Deep brain stimulation (DBS) offers Parkinson's disease (PD) patients improved quality of life over lesioning. While effective for tremor and rigidity, DBS may worsen speech and balance, with potential surgical risks.
Area of Science:
- Neurosurgery
- Neurology
- Movement Disorders
Background:
- Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease (PD).
- DBS offers better outcomes in mortality and quality of life compared to lesioning techniques like thalamotomy.
- It is indicated for severe, medically unresponsive tremor or motor complications.
Purpose of the Study:
- To review the efficacy and safety of DBS for Parkinson's disease.
- To outline indications, contraindications, and potential complications of DBS surgery.
- To compare DBS outcomes with those of lesioning procedures.
Main Methods:
- Review of existing literature on DBS for Parkinson's disease.
- Analysis of patient eligibility criteria for DBS.
- Summary of reported intra- and long-term surgical complications.
- Evaluation of DBS effects on various Parkinson's disease symptoms.
Main Results:
- DBS significantly improves tremor, rigidity, dystonia, and dyskinesias.
- Surgical risks include procedure abortion, lead misplacement, hemorrhage, and seizures.
- Long-term risks involve cognitive and psychiatric issues.
- Freezing, postural instability, and falls are not improved; verbal fluency and dysarthria may worsen.
Conclusions:
- DBS is a valuable treatment for select Parkinson's disease patients.
- Careful patient selection is crucial, excluding cognitive impairment.
- Potential complications and symptom-specific outcomes must be considered.
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