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Updated: Jun 23, 2026
A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
Published on: September 23, 2014
Tissue microarrays as a tool in the discovery and validation of tumor markers
1Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. genejock@helix.nih.gov
Abstract:
Tissue microarrays are a platform of condensed histopathology that has revolutionized the translation of basic science to clinical utility. Tissue microarrays have resulted in a paradigm shift from histopathology to immunopathology and moved analysis of small selected samples sets of tens of specimens to a high-throughput environment of hundreds of specimens. Tissue microarrays have influenced validation strategies, but have a role in discovery as well, allowing a pathways approach to analysis of tumors.
