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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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[Pathogenesis and treatment of vascular calcification in CKD]

D Brancaccio1, M Gallieni, S Pasho

  • 1Cattedra di Nefrologia, U.O. Nefrologia e Dialisi, A.O. San Paolo, Milano 20142, Italy. diego.brancaccio@unimi.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|April 22, 2009
PubMed

Insights

Vascular calcification, a complication of chronic kidney disease (CKD), contributes to cardiovascular events. Managing mineral and bone disorder (CKD-MBD) through targeted therapies can improve patient outcomes.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Context:

  • Vascular calcification is a significant complication in chronic kidney disease (CKD).
  • It is linked to increased cardiovascular events and mortality in CKD patients.
  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) encompasses metabolic derangements contributing to vascular calcification.

Purpose:

  • To elucidate the mechanisms of vascular calcification in CKD.
  • To highlight the role of CKD-MBD in this process.
  • To discuss therapeutic strategies for preventing and managing vascular calcification in CKD.

Summary:

  • Vascular calcification in CKD results from an active ossification process, influenced by bone proteins.
  • CKD-MBD involves abnormalities in bone turnover, mineralization, and vascular calcification.
  • Therapeutic interventions include controlling calcium, phosphate, parathyroid hormone, and utilizing specific medications.

Impact:

  • Understanding vascular calcification mechanisms is crucial for improving CKD patient prognosis.
  • Effective management of CKD-MBD can mitigate cardiovascular risks.
  • New therapeutic approaches aim to reduce mortality and enhance quality of life for CKD patients.

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