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Updated: Jun 23, 2026
Generation of Mesenchymal Stem Cells from Human Umbilical Cord Tissue and their Differentiation into the Skeletal Muscle Lineage
Published on: August 31, 2022
[Expression of metanephric differentiation markers in human mesenchymal stem cells]
F Bianchi1, G La Manna, S Cantoni
1Istituto di Nefrologia, Dialisi e Trapianto Renale, Ospedale S. Orsola, Istituto di Cardiologia-INBB, Universita' degli Studi, Bologna 40138, Italy. francib@alice.it
Abstract:
Stem cells are a potential source for the regeneration of many tissues, including damaged kidneys. The present study describes the adoption of hyaluronic- butyric acid monoesters (HB) to induce expression of nephrogenic genes by mesenchymal cells isolated from human placental membranes. HB at a concentration of 1 mg/mL induces chromatin opening and increases the expression of the observed markers (cadherin 11, CD24, RAR-alpha, stearoyl-CoA desaturase 2, 14-3-3 0, Ewing sarcoma homolog.). These results open new routes toward cell regeneration after kidney injury.
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