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Generation of Transgenic Hydra by Embryo Microinjection

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Important roles for epithelial cell peptides in hydra development.

Toshio Takahashi¹, Toshitaka Fujisawa

¹Suntory Institute for Bioorganic Research, Osaka 618-8503, Japan. takahashi@sunbor.or.jp

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|April 22, 2009

Summary

Researchers identified novel peptide signaling molecules, termed epitheliopeptides, in Hydra. These molecules are crucial for axial pattern formation and neuron differentiation during development.

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Area of Science:

Developmental Biology
Molecular Signaling
Zoology

Background:

Peptides are vital for tissue regulation in animals.
The role of peptides in developmental signaling is largely unknown.
Hydra exhibits evidence of morphogen-like signaling molecules in patterning.

Purpose of the Study:

To systematically identify peptide signaling molecules in Hydra.
To investigate the role of these peptides in developmental processes.

Main Methods:

Systematic identification of signaling molecules.
Review of existing evidence on morphogens in Hydra.

Main Results:

Identification of three specific peptide signaling molecules.
Identification of one peptide family functioning in signaling.
These peptides, termed epitheliopeptides, are produced by epithelial cells.
Epitheliopeptides regulate axial pattern formation and neuron differentiation in Hydra.

Conclusions:

Epitheliopeptides are key signaling molecules in Hydra development.
These findings highlight the importance of epitheliopeptides in hydrozoan development.