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Related Experiment Video

Updated: Jun 23, 2026

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

[Study on stability of oridonin solution].

Jie Xu¹, Jihui Zhao, Ju Wang

¹Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|April 23, 2009

Summary

This summary is machine-generated.

Oridonin (ORI) solutions are unstable, degrading rapidly at room temperature and 4°C. Stability is pH-dependent, indicating specific acid-base catalysis is involved in oridonin degradation.

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Area of Science:

Pharmacology
Chemical kinetics
Drug formulation

Context:

Oridonin (ORI) is a key compound in traditional Chinese medicine with potential therapeutic applications.
Developing stable oridonin preparations is crucial for its effective use in research and clinical settings.
Understanding the degradation pathways of oridonin is essential for optimizing its formulation and storage.

Purpose:

To investigate the stability of oridonin (ORI) solutions under various conditions.
To evaluate the impact of pH on the degradation rate of oridonin.
To determine the shelf-life of oridonin solutions at different temperatures.

Summary:

Oridonin solution stability was assessed by monitoring degradation rates at varying pH levels and temperatures (room temperature and 4°C).
The pH-rate profile exhibited a V-shaped curve with a minimum degradation rate at pH 5.
Oridonin solutions demonstrated limited stability, with a t90 (time for 10% degradation) of 53.2 hours at room temperature and 91.5 hours at 4°C.

Impact:

The findings highlight the instability of oridonin solutions, necessitating careful formulation strategies.
The pH-dependent degradation suggests specific acid-base catalysis, providing insights for stabilizing oridonin.
This research is vital for the development of novel, stable oridonin preparations for pharmaceutical use.