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[Effects of Sarcandra glabra extract on immune activity in restraint stress mice]
Rongrong He1, Min Wang, Yifang Li
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. rongronghe66@163.com
Objective:
To study the protective effect of Sarcandra glabra extract (SGE) on immune system in restrained mice.
Method:
The male C57BL/6 mice were randomly divided into normal control group, stress control group, 125, 500 mg x kg(-1) SGE group. The spleen lymphocyte suspensions of each group were prepared. The parameters of spleen T cells subsets, NK cell and NKT cell proportion and number was detected by Flow cytometry.
Result:
SGE regulated the balance of T cell subsets, increased the percent of NK cells and NKT cell proportion and number in restrained mice.
Conclusion:
SGE has immunologic protective effect in restrained mice probably via the amelioration of immune cells proportion and number.
