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Updated: Jun 23, 2026

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
What role for human rhinoviruses in the lower respiratory tract?
Cristina Costa1, Massimiliano Bergallo, Francesca Sidoti
1SCDU Virologia, Dipartimento di Sanità Pubblica e Microbiologia, Azienda Ospedaliera Universitaria San Giovanni Battista, Via Santena, 9-10126 Torino. cristina.costa@unito.it
Abstract:
Human rhinoviruses (HRV) usually cause upper airway infections. However, viral replication in the tracheobronchial tree has been disclosed, although its clinical role is poorly known. We evaluated the prevalence of HRV in 159 bronchoalveolar lavages from 88 patients and describe a lung transplant recipient with a high HRV load in association with acute rejection. HRV was detected in 22/88 patients (25.0%): 7/18 lung transplant recipients, 11/41 immunocompetent, and 4/29 immunocompromised (p = n.s.). No lung disease was significantly associated with HRV positivity. It should be recommended to include HRV in the virological diagnostic work-up of lower respiratory specimens to elucidate their role.
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