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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: Jun 23, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

How research can help control tuberculosis.

R E Chaisson1, M Harrington

  • 1Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, USA. rchaiss@jhmi.edu

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|April 23, 2009
PubMed
Summary
This summary is machine-generated.

Tuberculosis (TB) research has stagnated despite available tools, leading to control failures. Increased investment in basic and applied research is crucial for developing new diagnostics, drugs, vaccines, and effective population-level strategies to combat this persistent global threat.

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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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Published on: March 24, 2017

Area of Science:

  • Biomedical Science
  • Infectious Disease Research
  • Public Health

Background:

  • Tuberculosis (TB) has a long history in biomedical science, with significant progress in diagnostics, therapeutics, and prevention in the 20th century.
  • TB research funding dramatically decreased after the development of short-course chemotherapy, leading to stalled progress in disease control.
  • Current TB control is hampered by existing tool limitations and inadequate implementation, exacerbated by rising rates of HIV-related TB and multidrug-resistant TB.

Purpose of the Study:

  • To highlight the critical need for a revitalized and robust tuberculosis research enterprise.
  • To identify key areas for future TB research, including basic science, biomedical tools, and population-level application strategies.
  • To emphasize the inadequacy of current global funding for TB research in meeting global control goals.

Main Methods:

  • Historical review of TB research and its impact on disease control.
  • Analysis of current challenges in TB epidemiology, including HIV co-infection and drug resistance.
  • Assessment of research priorities for diagnostics, therapeutics, vaccines, and implementation science.

Main Results:

  • Despite historical successes, TB remains a major global killer due to tool shortcomings and implementation gaps.
  • Emerging challenges like HIV-related TB and multidrug-resistant TB necessitate urgent research advancements.
  • Existing global funding for TB research is insufficient to meet ambitious control targets.

Conclusions:

  • A comprehensive research agenda is essential for achieving global tuberculosis control goals in the 21st century.
  • Significant investment is required in basic science for understanding pathogenesis and identifying new targets.
  • Research must focus on developing improved biomedical tools and effective population-level application strategies for TB control.