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Reactive nitrogen intermediate susceptibility of Mycobacterium tuberculosis genotypes in an urban setting
V T G Inumaru1, P A Nogueira, I V Butuem
1Faculdade de Saúde Pública, University of Sao Paulo, Sao Paulo, Brazil.
Background:
Mycobacterium tuberculosis genotypes resistant to reactive nitrogen intermediates (RNI) predominate in certain urban communities, suggesting that this phenotype influences disease transmission.
Objective:
To compare different M. tuberculosis genotypes for resistance to RNI generated in vitro.
Design:
We genotyped 420 M. tuberculosis isolates from a neighborhood in Sao Paulo, Brazil, and analyzed them for susceptibility to RNI generated in acidified sodium nitrite (ASN) solution.
Results:
Seventy-one (43%) of 167 recent-infection strains and 68 (43%) of 158 endogenous infection strains showed moderate- to high-level ASN resistance.
Conclusion:
ASN resistance of M. tuberculosis is not necessarily a determining factor for enhanced transmission.
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