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Association between renin-angiotensin system gene polymorphism and recurrent wheezing in Chinese children: a 4-year

S Guo1, J H Zhang, Y D Yan

  • 1Department of Paediatrics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

The Journal of International Medical Research
|April 23, 2009
PubMed

Insights

The angiotensin-converting enzyme (ACE) DD genotype is linked to recurrent infant wheezing and asthma. This finding may aid in predicting persistent wheezing in children.

Area of Science:

  • Genetics
  • Pediatrics
  • Immunology

Background:

  • Infant wheezing and childhood asthma are significant health concerns.
  • Genetic factors, including angiotensin-converting enzyme (ACE) gene polymorphisms, are implicated in respiratory conditions.
  • Early identification of children at risk for persistent wheezing and asthma is crucial for timely intervention.

Purpose of the Study:

  • To investigate the association between angiotensin-converting enzyme (ACE) gene polymorphisms and infant wheezing.
  • To determine if ACE gene variants can predict persistent wheezing and the development of asthma in early childhood.

Main Methods:

  • A cohort study involving 149 asthma patients, 169 wheezing patients, and 165 healthy controls.
  • Polymerase chain reaction (PCR) was used to determine the insertion/deletion (I/D) polymorphism of the ACE gene.
  • Serum total immunoglobulin E levels were measured, and a 4-year follow-up assessed wheezing relapse.

Main Results:

  • Significant differences in ACE allele frequency and genotype distribution were observed between patient and control groups.
  • The DD genotype of the ACE gene was more prevalent in children with wheezing and asthma compared to controls.
  • Individuals with the DD genotype exhibited a higher frequency of wheezing relapse.

Conclusions:

  • The DD genotype of the angiotensin-converting enzyme (ACE) gene is a significant risk factor for recurrent wheezing in early childhood.
  • ACE gene polymorphism may serve as a potential biomarker for predicting persistent wheezing and asthma development.
  • Further research into genetic predispositions can enhance early diagnosis and management strategies for pediatric respiratory illnesses.

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