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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Thymidylate synthase gene variations: predictive and prognostic markers.

Georg Lurje1, Philipp C Manegold, Yan Ning

  • 1Division of Medical Oncology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.

Molecular Cancer Therapeutics
|April 23, 2009
PubMed
Summary

This review examines thymidylate synthase (TS) pharmacogenomics in 5-fluorouracil (5-FU) chemotherapy. Understanding TS genetic variations can personalize cancer treatment and improve patient outcomes.

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