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Imaging thermally damaged tissue by Polarization Sensitive Optical Coherence Tomography.

J De Boer, S Srinivas, A Malekafzali

|April 23, 2009

Summary

Polarization Sensitive Optical Coherence Tomography (PS-OCT) images thermal damage by detecting reduced birefringence in tissues. This technique shows potential for assessing burn depth in biological materials like skin and tendon.

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Area of Science:

Biomedical Optics
Medical Imaging
Tissue Optics

Background:

Biological tissues possess birefringence, particularly fibrous structures like collagen.
Thermal damage denatures collagen, reducing its birefringence.
This change in birefringence can serve as an optical marker for thermal injury.

Purpose of the Study:

To investigate the use of Polarization Sensitive Optical Coherence Tomography (PS-OCT) for imaging thermal damage.
To assess the reduction of birefringence in biological tissues subjected to thermal insult.
To demonstrate the potential of PS-OCT for burn depth assessment.

Main Methods:

Utilized PS-OCT to simultaneously detect fringe signal amplitudes in orthogonal polarization states.
Measured changes in polarization due to optical phase delay in birefringent media.
Employed a Michelson interferometer setup with simultaneous detection of backscattered light and reference arm interference.

Main Results:

Successfully imaged the reduction of birefringence in thermally damaged porcine tendon and skin.
Observed a decrease in birefringence correlating with thermal denaturation of collagen (56-65°C).
Demonstrated PS-OCT's capability to visualize structural changes indicative of thermal damage.

Conclusions:

PS-OCT is a viable technique for imaging birefringence changes in biological tissues.
The reduction in birefringence serves as a reliable optical marker for thermal damage.
PS-OCT shows significant potential for non-invasive burn depth assessment.