Related Experiment Video
Updated: Jun 23, 2026
07:39
Corneal and Limbal Alkali Injury Induction Using a Punch-Trephine Technique in a Mouse Model
Published on: August 4, 2023
[Isolated conjunctival involvement in Langerhans cell histiocytosis]
M López-Molina1, M Méndez-Llatas, L Sáez-Méndez
1Servicio de Oftalmología, Complejo Hospitalario Universitario de Albacete, Albacete, España. mercedeslopezmolina@hotmail.com
Archivos De La Sociedad Espanola De Oftalmologia
|April 23, 2009
Summary
Langerhans cell histiocytosis (LCH) can affect the conjunctiva, a rare presentation. This case highlights the importance of histopathology for diagnosing isolated conjunctival LCH.
Area of Science:
- Ophthalmology
- Histopathology
- Oncology
Background:
- Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder of Langerhans cells.
- While LCH commonly affects multiple organs, isolated ocular involvement is infrequent.
Observation:
- A 43-year-old woman presented with a hyperemic conjunctival node unresponsive to topical antibiotics and anti-inflammatories.
- Biopsy-extirpation was performed due to lack of clinical improvement.
Findings:
- Histopathological and immunohistochemical analyses confirmed Langerhans cell histiocytosis (LCH).
- Extensive clinical and analytical investigations revealed no extraocular manifestations, indicating isolated conjunctival LCH.
Implications:
- This case underscores the necessity of histopathological examination for diagnosing rare ocular presentations of LCH.
- The successful diagnosis and management of isolated conjunctival LCH contribute to understanding its diverse clinical spectrum.
